Modulation of brain resting-state networks by sad mood induction

Abstract

Background: There is growing interest in the nature of slow variations of the blood oxygen level-dependent (BOLD) signal observed in functional MRI resting-state studies. In humans. these slow BOLD variations are thought to reflect an underlying or intrinsic form of brain functional connectivity in discrete neuroanatomical systems. While these resting-state networks' maybe relatively enduring phenomena, other evidence suggest that dynamic changes in their functional connectivity may also emerge depending on the brain state subjects during scanning. Methodology/Principle Findings: In this study, we examined healthy subjects (n-24) with a mood induction paradigm during two continuous fMRI reco..